Welcome to THOIPA!

THOIPA (Transmembrane Homodimer Interface Prediction Algorithm) is a web server developed for the prediction of interface residues. It is designed for the transmembrane helix homodimers of single-pass membrane proteins. It can also be applied to predict the interface residues of self-interacting helices within multi-pass membrane proteins.

Please input the transmembrane protein name here:   
Please paste the full amino acid sequence of a transmembrane protein, in fasta format (Example)


or upload a file:

Please paste the sequence of a single transmembrane segment(Example)





If you wish to cite THOIPA, please refer to our publication:

Xiao,Y*., Zeng,B*., Nicola Berner, Frishman,D., Langosch,D., Teese,M.-G. Experimental determination and data-driven prediction of homotypic transmembrane domain interfaces.(* equal contribution)